Scientific Program


Thursday, June 29th, 2017

From 16:00

Arrival and registration and Check-In

17:00 - 18:30

Welcome reception


Opening Session

18:30 - 18:35


18:35 - 19:20

Keynote Lecture 1
Cotranslational protein folding
Gunnar von Heijne (Stockholm University, Sweden)

19:20 - 20:05

Keynote Lecture 2
An integrated, structure- and energy-based view of decoding
Eric Westhof (IBMC/CNRS Strasbourg)




Friday, June 30th, 2017




RNA fate and localization
Chair: Ayala Shiber

09:00 - 09:30

Non-invasive measurement of mRNA degradation reveals translation initiation as the major determinant of transcriptome stability
Karsten Weis    (ETH Zurich, Switzerland)

09:30 - 10:00

Translation regulation during macrophage activation
Georg Stöcklin (ZMBH Mannheim)       

10:00 - 10:30

Identification of the interactome of a localized mRNA by mRNA proximity biotinylation
Ralf Jansen (Eberhard-Karls University Tübingen, Germany)                                   

10:30 - 11:00

Mechanistic insights into specific mRNA transport in budding yeast
Dierk Niessing (LMU Munich, Germany)

11:00 - 11:20

Structural dynamics of pre-mRNA splicing
Karl Bertram (MPI Göttingen, Germany)


Note ST Short talk



11:20 - 11:45

Coffee Break




RNA modifications
Chair: Zoya Ignatova

11:45 - 12:15

N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
Shu-Bing Qian  (Cornell University, Ithaka, NY, USA)                                                   

12:15 - 12:45

Distribution and function of cytosine-5 RNA methylation
Frank Lyko (DKFZ Heidelberg, Germany)

12:45 - 13:15

Analytics of RNA Modifications
Marc Helm (Johannes-Gutenberg University of Mainz, Germany)

13:15 - 15:00


15:00 - 15:30

The absence of tRNA modifications affects translation differently in different species
Sebastian Leidel (MPI Münster, Germany)       


Stress granules in translation: A multifaceted structure with unknown implications
Maximilian Anders (Univ. Hamburg)




Innovative technologies
Chair: Birgitta Beatrix                                                                                                   

15:50 - 16:20

Co-evolution of translation initiation factor 4A and its natural inhibitor rocaglates in Aglaia
Shintaro Iwasaki (RIKEN Tokyo, Japan)                              

16:20 - 16:50

We will review the current status of the field and present new data on RQC mechanisms
Khanh Dao Duc (University of Pennsylvania, USA)         

16:50 - 17:20

Coffee Break    

17:20 - 17:50

Real-time dynamics of mRNA translation in living cells
Marvin Tanenbaum (Hubrecht Institute, Utrecht)

17:50 - 18:20

Zooming into translatomes with ribosome profiling
Pavel Baranov  (University College Cork, Ireland)

18:00 - 18:25

Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation
Jan-Stefan Völler (TU Berlin, Germany)

18:50 - 19:10

Studying the Nascent Peptide Chain in the Ribosomal Exit Tunnel
Nadine Haase (MPI Göttingen, Germany)








Saturday, July 1th, 2017




Nascent chain biology
Chair: Günter Kramer

09:00 - 09:30

Substrate specificity, action and interplay of co-translational acting N-terminal acetyltransferases and methionine aminopeptidases
Petra Van Damme (Ghent University, Belgium)                                                              

09:30 - 10:00

Membrane protein biogenesis between ribosome and translocon
Martin Spiess (Biocenter Basel, Switzerland)                                                                   

10:00 - 10:30

Some Y’s and How’s of membrane protein biogenesis in bacteria
Alexej Kedrow (LMU Munich, Germany)                                                                          

10:30 - 10:50

Co-translational protein complex assembly in eukaryotes revealed by ribosome profiling, at near residue resolution
Ayala Shiber (ZMBH Heidelberg, Germany)       

10:50 - 11:10

Stochastic modeling of multiprotein complexes
Stefanie Förste  (MPI Göttingen, Germany)



11:10 - 11:30

Coffee Break




mRNA surveillance and ribosome quality control
Chair: Thomas Becker

11:30 - 12:00

Ubiquitination of uS10 by Hel2 and RQT complex triggers Ribosome-associated Quality Control Toshifumi Inada (Tohoku University Sendai, Japan)                                                    

12:00 - 12:30

Ribosome-Associated Quality Control (RQC)
Claudio Joazeiro(ZMBH Heidelberg, Germany)                                                             

12:30 - 13:00

Nonsense mediated mRNA decay in budding yeast: impact on gene expression and biochemical characterization
Alain Jacquier   (Institut Pasteur, Paris, France)                                                                            

13:00 - 13:20

High-resolution cryo-EM structure of a ribosome-Ski complex reveals interactions between the translation and 3’-5’ mRNA degradation machineries
Christian Schmidt(LMU Munich, Germany)



13:20 - 14:00





Free afternoon/excursion




Sunday, July 2th, 2017




Translational mechanisms
Chair: Andre Heuer

09:00 - 09:30

Protein synthesis in organelles at cryo-EM resolution
Alexej Amunts (Stockholm University, Sweden)                                                            

09:30 - 10:00

Dynamics aspects of translation initiation and its control in bacteria with evolutionary considerations
Stefano Marzi   (CNRS Strasbourg)                                                                                      

10:00 - 10:20

Antimicrobial peptide apidaecin traps release factors on the ribosome
Michael Gräf (University Hamburg, Germany)                

10:20 - 10:40

The mechanism of ribosome subunit joining during translation initiation
Hiroshi Yamamoto (Charité Berlin, Germany)                                 



10:40 - 11:10

Coffee break



11:10 - 11:30

Quantifying the translational fidelity by targeted mass spectrometry
Ingo Wohlgemuth(MPI Göttingen, Germany)                               

11:30 - 11:50

Investigation of native ex vivo derived 70S-polysomes by cryo-EM
Jan-Torben Chrsitiansen (Charité Berlin, Germany)      

11:50 - 12:10

AMD1 mRNA employs ribosome queuing as a mechanism for molecular memory formation
Martina Yordanova (Univ. College Cork)



12:10 - 13:40




14:00 - 16:00

Poster Session II




Structural and computational approaches
Chair: Andrea Vaiana

16:30 - 17:00

Into the core of the giant ribosomes
Pascal Auffinger (IMNB/CNRS Strasbourg, France)                                                      

17:00 - 17:30

Mechanisms of Codon Reading and Peptidyl-tRNA Hydrolysis in Termination of Translation
Johan Åqvist (Uppsala University, Sweden)                                                                     

17:30 - 17:50

Complementing structural information with dynamics and energetics from molecular dynamics simulations to gain insight into mechanisms of ribosomal elongation
Lars Bock (MPI Göttingen, Germany)   



17:50 - 18:00

End of the meeting Summary




Gala dinner




Monday, July 3rd, 2017




Breakfast and departure



Confirmed Speakers

Alexey Amunts, University of Stockholm, Sweden
Johan Åqvist, University of Uppsala, Sweden
Pascal Auffinger, CNRS Strasbourg, France
Pasha Baranov, University College Cork, Ireland
Khanh Dao Duc, University of Pennsylvania, USA
Mark Helm, University of Mainz, Germany
Toshifumi Inada, Tohoku University, Japan
Shintaro Iwasaki, Riken, Japan
Ralf Jansen, University of Tuebingen, Germany
Alain Jacquier, Institut Pasteur, France
Claudio Joazeiro, University of Heidelberg, Germany
Alexej Kedrov, Gene Center Munich, Germany
Sebastian Leidel, Max Planck Institute for Molecular Biomedicine, Münster
Frank Lyko, DKFZ Heidelberg, Germany
Stefano Marzi, CNRS Strasbourg, France
Dierk Niessing, LMU Munich, Germany
Shu-Bing Qian, Cornell University, USA
Martin Spiess, Biocenter Basel, Switzerland
Georg Stöcklin, University of Heidelberg, Germany
Marvin Tanenbaum, Hubrecht Institute, The Netherlands
Petra Van Damme, Ghent University, Belgium
Gunnar von Heijne, University of Stockholm, Sweden
Karsten Weis, ETH Zurich, Switzerland
Eric Westhof, University of Strasbourg, France